KISSPEPTIN-10 10 MG

Kisspeptin is a hypothalamic peptide encoded by the KISS1 gene that acts as a master regulator of the reproductive axis by stimulating gonadotropin-releasing hormone (GnRH) release. It is critical for initiating puberty, controlling fertility, and mediating sex steroid feedback. Known as a key "KNDy" neuron regulator, it is being researched for treating infertility and hypoactive sexual desire disorder.

National Institutes of Health (.gov) +4

Key Aspects of Kisspeptin Peptide

• Mechanism: Kisspeptin binds to the KISS1R receptor (GPR54) on GnRH neurons, triggering the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

• Isoforms & Structure: Derived from the KISS1 gene, it exists in multiple forms, including kisspeptin-54 (KP-54) and the more commonly researched shorter fragment, kisspeptin-10 (KP-10).

• Clinical Applications:

  • Infertility: Used to trigger oocyte maturation in IVF, serving as a safer alternative to hCG in high-risk patients.

  • Reproductive Disorders: Studied for treating hypothalamic amenorrhea.

  • Sexual Function: Emerging evidence suggests it may boost sexual brain activity in women with low sexual desire.

• Clinical Findings: Research shows that both KP-54 and KP-10 are safe in humans and effective at increasing LH levels.

• Other Roles: Besides reproduction, kisspeptin is involved in cancer metastasis inhibition (initially named "metastin") and potential protective effects against amyloid-beta toxicity. 

Kisspeptin is increasingly recognized for its therapeutic potential in reproductive health, offering a way to modulate the hormonal axis directly.