PNC-27 10mg
High Purity Peptide Solution
CA$195.00
Out of stock
PNC-27 is an experimental anti-cancer peptide that selectively induces membrane-pore formation and necrotic cell death in various cancer cells (including solid tumors and leukemia) while leaving normal cells unharmed. It targets the HDM-2 protein present on cancer cell membranes and shows potential in treating chemotherapy-resistant cancers.
Key Potential Benefits and Mechanisms:
Selective Cancer Cell Killing: Unlike traditional chemotherapy, PNC-27 induces necrosis specifically in cancer cells by binding to HDM-2 on the plasma membrane, causing membrane-pore formation and cell lysis.
No Effect on Normal Cells:
Studies have shown that PNC-27 does not harm normal, healthy cells, as they do not express the same membrane-bound HDM-2
.
Effective Against Resistant Cancers: PNC-27 has demonstrated cytotoxicity in chemotherapy-resistant cancer cells and, according to MDPI, works on a wide variety of solid tissue and blood-based tumors.
Alternative Mechanism of Action: It is highly effective for cancers that do not respond to conventional treatments by causing rapid tumor cell necrosis.